Data from: Pattern of polyphenol intake and the long-term risk of dementia in older persons

Objective: To investigate the optimal combination of dietary polyphenols
associated with the long-term risk of dementia in a large prospective
French cohort of older persons, the Three-City (3C) Study. Methods: We
included 1,329 non-demented older adults from the 3C Study with assessment
of intake of 26 polyphenol subclasses and followed for 12 years for
dementia. Using Partial Least Square for Cox models, we identified a
pattern of polyphenol intake associated with dementia risk. Results: The
pattern combined several flavonoids (dihydroflavonols, anthocyanins,
isoflavonoids, flavanones), stilbenes (including resveratrol), lignans and
other subclasses (hydroxybenzaldehydes, naphtoquinones, furanocoumarins).
Compared with participants in the lower quintile of pattern score, those
in the higher quintile had a 50% lower risk of dementia (95% CI 20%; 68%,
p-trend <0.01) in multivariate models. Conclusions: In this French
cohort, a polyphenol pattern provided by a diet containing specific plant
products (nuts, citrus, berries, leafy vegetables, soy, cereals, olive
oil) accompanied with red wine and tea was associated with lower dementia
risk.