Human prolyl endopeptidase (PREP) - complex with JP-7-1-7

Human prolyl endopeptidase (PREP) - complex with JP-7-1-7 Descriptor: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-chloro-1-(2-cyclohexylethyl)-3-methyl-N-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxamide, DI(HYDROXYETHYL)ETHER, ... Authors: Fucci, I.J, Thakur, K, Pandian, J, Yoo, E, Monteiro, D.C.F. Deposit date: 2025-08-26 Release date: 2026-01-21 Last modified: 2026-02-04 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Structure-Guided Optimization of 4-Chloro-Pyrazolopyridine Analogs for Covalent PREP Inhibition. J.Med.Chem., 69, 2026