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Designed Oligooxopiperazines as Modulators of Hypoxia-Inducible Factor Signaling

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NIAID Data Ecosystem2026-03-10 收录
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We performed gene expression profiling of oligooxopiperazines (OPs) targeting the hypoxia-inducible transcription factor complex. Treatment of cells with OPs inhibited hypoxia-inducible gene expression in A549 cells. Hypoxic A549 cells were treated with transcriptional inhibitors BB2-162, BB2-125, BB2-282 or vehicle and their expression profiles were compared to normoxic A549 cells treated with vehicle.

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2018-07-26
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