Crystal structure of the human METTL3-METTL14 complex with compound ASI_M3M_041

Crystal structure of the human METTL3-METTL14 complex with compound ASI_M3M_041 Descriptor: ACETATE ION, N-[[(3R)-3-Hydroxy-1-[6-(methylamino)pyrimidin-4-yl]piperidin-3-yl]methyl]-4-(piperidin-1-ylmethyl)benzamide, N6-adenosine-methyltransferase catalytic subunit, ... Authors: Bedi, R.K, Huang, D, Caflisch, A. Deposit date: 2021-02-10 Release date: 2021-10-20 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 Acs Bio Med Chem Au, 2023人源METTL3-METTL14复合物结合化合物ASI_M3M_041的晶体结构 描述符：乙酸根离子、N-[[(3R)-3-羟基-1-[6-(甲氨基)嘧啶-4-基]哌啶-3-基]甲基]-4-(哌啶-1-基甲基)苯甲酰胺、N6-腺苷甲基转移酶催化亚基…… 作者：Bedi, R.K、Huang, D、Caflisch, A 存入日期：2021-02-10 发布日期：2021-10-20 最后修改日期：2024-10-16 实验方法：X射线衍射（分辨率2.5埃） 引用：《靶向m6A RNA写入酶METTL3抑制剂的基于结构设计》，发表于Acs Bio Med Chem Au, 2023