The serum levels of BTMs in healthy women and in breast cancer patients prior to and after neoadjuvant chemotherapy.

Data are reported as mean ± SD.
*Statistically significant at P < 0.05;
†Statistically significant at P < 0.01.
ICTP, carboxyterminal cross-linked telopeptide of type I collagen; β-Crosslaps, β-isomer of C-terminal telopeptide of type I collagen; BAP, bone-specific alkaline phosphatase; PINP, procollagen type I N-terminal propeptide.
C0, the initial diagnosis day before chemotherapy;
C4, 24 hours after the fourth cycle of chemotherapy.
Pa: comparison between the healthy control and the patients at the baseline (C0).
Pb: comparison between the baseline (C0) and after the 4th cycle of chemotherapy (C4) in patients
The serum levels of BTMs in healthy women and in breast cancer patients prior to and after neoadjuvant chemotherapy.