Genes demonstrating genome-wide significant evidence of rare variant association with type-1 diabetes on chromosome 6.

aGenes with a permuted p-value less than 1.7×10−6 (indicating genome wide significance assuming a significance level of 5% and that there are 30,000 genes in the human genome [25]) in a Generalised C-alpha test.bFor these genes, results are also shown when effects are adjusted for the lead common MHC SNP (rs9268645). Both analyses are adjusted for 3 principal components to account for population structure. For the unconditional analysis results are based on 600,000 permutations; for the conditional analysis results are based on 575,000 permutations. MAF, minor allele frequency; BP, base pair; MAF: Minor Allele Frequency; MHC, Major histocompatibility complex; NCBI, National Center for Biotechnology Information.