Crystal structure of the second bromodomain (BD2) of human TAF1 bound to PLK1 kinase inhibitor BI2536
收藏Protein Data Bank Japan2023-10-18 更新2026-03-21 收录
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Crystal structure of the second bromodomain (BD2) of human TAF1 bound to PLK1 kinase inhibitor BI2536 Descriptor: 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, Transcription initiation factor TFIID subunit 1 Authors: Karim, M.R, Schonbrunn, E. Deposit date: 2020-09-06 Release date: 2021-09-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.52 Å) Cite: Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022
人源TAF1（全称为转录起始因子TFIID亚基1）的第二个溴结构域（bromodomain，BD2）与PLK1激酶抑制剂BI2536结合的晶体结构
配体标识符：4-{[(7R)-8-环戊基-7-乙基-5-甲基-6-氧代-5,6,7,8-四氢蝶啶-2-基]氨基}-3-甲氧基-N-(1-甲基哌啶-4-基)苯甲酰胺
作者：Karim, M.R.、Schonbrunn, E.
提交日期：2020-09-06
发布日期：2021-09-22
最后修改日期：2023-10-18
实验方法：X射线衍射（分辨率2.52埃）
引用文献：《双靶点TAF1-ATR抑制剂的发现及TAF1串联溴结构域的配体诱导构象变化》，J.Med.Chem., 65, 2022
创建时间：
2020-09-06
