The dysregulation of gene dosage due to duplication or haploinsufficiency is a major cause of autosomal dominant diseases such as Alzheimer's disease. However, there is no rapid and efficient method f
Diffuse intrinsic pontine gliomas (DIPGs) are highly lethal childhood brain tumors. Their unique genetic makeup, pathological heterogeneity, and brainstem location all present challenges to treatment.
We generated knockout lines of the antenna protein Lhcx1 in Phaeodactylum tricornutum using a TALEN approach. We designed two TALEN pairs and greated three knockout lines (x1KO_1a/1b and x1KO_2)
