SLC2A3 gene expression is stimulated by MECP2:CREB1 complex

Based on studies in mice, transcription of the SLC2A3 (GLUT3) gene, encoding solute carrier family 2, facilitated glucose transporter member 3, is directly stimulated by the complex of MECP2 and CREB1. In the mouse brain, expression of the Slc2a3 gene is developmentally regulated, peaking at postnatal day 14, which correlates with hypermethylation of the 5' flanking region CpG island (Chen et al. 2013).

基于对小鼠的研究，SLC2A3（GLUT3）基因的转录，编码载体家族2的葡萄糖转运蛋白3成员，受到MECP2与CREB1复合体的直接激活。在小鼠大脑中，Slc2a3基因的表达受发育调控，于出生后第14天达到峰值，这与5'侧翼区域的CpG岛高甲基化相关（Chen等，2013年）。