International Consortium for Blood Pressure (ICBP)

The ICBP consortium is an international effort to investigate blood-pressure genetics. The consortium was formed by two parent consortia, the CHARGE-BP consortium (Cohorts for Heart and Aging Research in Genomic Epidemiology - blood pressure) and the GBPGEN consortium (Global Blood Pressure Genetics Consortium). In 2011 we performed genome-wide association analyses based on genome-wide SNPs imputed to HapMap for systolic and diastolic blood pressure (SBP and DBP) and mean arterial pressure and pulse pressure (MAP and PP). In 2016 we performed an analysis based on the Cardio-MetaboChip for SBP and DBP. All these datasets are available here, however, full association statistics including effect size directions, only under controlled access by dbGaP.]]>
We performed genome-wide association analyses based on genome-wide SNPs imputed to HapMap per study for systolic blood pressure (SBP). Covariates were age, age2,BMI, and sex. In the presence of anti-hypertensive medication, the BP was corrected by adding a constant (15mmHg for SBP). The individual study results were meta-analyzed.We performed genome-wide association analyses based on genome-wide SNPs imputed to HapMap per study for diastolic blood pressure (DBP). Covariates were age, age2,BMI, and sex. In the presence of anti-hypertensive medication, the BP was corrected by adding a constant (10mmHg for DBP). The individual study results were meta-analyzed.We performed genome-wide association analyses based on genome-wide SNPs imputed to HapMap per study for Pulse Pressure (PP). Covariates were age, age2,BMI, and sex. In the presence of anti-hypertensive medication, the BP was corrected by adding a constant (15mmHg for SBP and 10mmHg for DBP). The individual study results were meta-analyzed.We performed genome-wide association analyses based on genome-wide SNPs imputed to HapMap per study for Mean Arterial Pressure (MAP). Covariates were age, age2,BMI, and sex. In the presence of anti-hypertensive medication, the BP was corrected by adding a constant (15mmHg for SBP and 10mmHg for DBP). The individual study results were meta-analyzed.Primary objective is to discover new blood pressure loci and confirm published loci. Platform is the Illumina Cardio-MetaboChip, a number of studies imputed to HapMap, and a few studies imputed to 1000G. The total maximal sample size is 201,529. SBP and DBP were analyzed, corrected for age, age^2, BMI, sex and principal components where appropriate. (The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. AOP Nature Genetics 05 September 2016, doi:10.1038/ng.3667)Primary objective is to discover new blood pressure loci and confirm published loci. Platform is the Illumina Cardio-MetaboChip, a number of studies imputed to HapMap, and a few studies imputed to 1000G. The total maximal sample size is 201,529. SBP and DBP were analyzed, corrected for age, age^2, BMI, sex and principal components where appropriate. (The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. AOP Nature Genetics 05 September 2016, doi:10.1038/ng.3667)Exclusion criteria varied slightly for each study and can be found in the Supplementary Materials of Nature. 2011 Sep 11;478(7367):103-9, Nature Genetics. 2011 Sep 11;43(10):1005-11, and Nature Genetics, 2016 Sept 12;48(10):1171-84 (PMID: 27618452).]]>
2013 - First Study Release (GWAS Analyses Data) 2016 - Second Study Release (Cardio - Metabochip Analyses Data) ]]>