Degrees of protein fold disruption in natural and simulated HIV-1 recombinants.

1The p-value is the probability that mimic recombination breakpoints do not tend to avoid disrupting protein folding to a greater degree than S-recombinants.2Covarying contact model of coevolution. Amino acids within van der Waals contact in the 3D structure were considered to be potentially covarying. The p-value is determined from a comparison of observed numbers of coevolving residues that are segregated by recombination with numbers predicted under random recombination.3Mutual information model of coevolution. Amino acids in contact in the 3D structure with associated mutual information values >0.25 were considered to be potentially covarying. P-values were determined as in 2.4Not determined.