Experimental design and effects of post-training muscimol infusions to cerebellar cortex and nuclei on consolidation.

Experimental design: each daily session is shown as an open rectangle. Solid vertical lines indicate 3 day rest periods. Post-training cortical and nuclear infusions of muscimol (closed arrows) or vehicle (open arrows) are indicated. Behavioral data: daily, mean session %CRs (±1 SEM) for the Control (cortical and nuclear vehicle, n = 4) and Cortex+Nucleus (cortical and nuclear muscimol, n = 4) groups. Control subjects acquired asymptotic CRs during Phase 1, but Cortex+Nucleus subjects did not. Cortex+Nucleus subjects developed robust CRs during Phase 2, when muscimol was not given. Post-training infusions of muscimol given to the Control subjects during Phase 3 had no consequences for the maintained expression of CRs during Phases 3 and 4.