Functional interactions among neurons within single columns of macaque V1

Recent developments in high-density neurophysiological tools now make it possible to record from hundreds of single neurons within local, highly interconnected neural networks. Among the many advantages of such recordings is that they dramatically increase the quantity of identifiable, functional interactions between neurons thereby providing an unprecedented view of local circuits. Using high-density, Neuropixels recordings from single neocortical columns of primary visual cortex in nonhuman primates, we identified 1000s of functionally interacting neuronal pairs using established crosscorrelation approaches. Our results reveal clear and systematic variations in the synchrony and strength of functional interactions within single cortical columns. Despite neurons residing within the same column, both measures of interactions depended heavily on the vertical distance separating neuronal pairs, as well as on the similarity of stimulus tuning. In addition, we leveraged the statistical powe...近年来，高密度神经生理学工具的发展已实现对局部高度互连神经网络内数百个单个神经元的记录。此类记录的核心优势之一在于，其可大幅提升神经元间可识别的功能相互作用的数量，从而为局部神经环路提供前所未有的观测视角。本研究通过对非人灵长类动物初级视觉皮层（primary visual cortex）单个新皮层柱（neocortical column）开展高密度神经像素探针（Neuropixels）记录，利用已成熟的交叉相关分析方法，鉴定出数千对存在功能相互作用的神经元对。研究结果显示，单个皮层柱内功能相互作用的同步性与强度存在显著且系统性的变化。尽管神经元同处于一个皮层柱内，但这两项相互作用的衡量指标均显著依赖于神经元对之间的垂直间距，以及其刺激调谐特性的相似性。此外，本研究借助其统计效力……（原文此处未完整呈现）