Deep sequencing of faecal DNA viromes from 647 healthy Danish infants

The COPSAC2010 cohort of Danish children is a population-based cohort where viromes were extracted and deeply sequenced for age 1 year faecal samples. The children in the cohort were all born around 2010, but their mothers were recruited for the study already during pregnancy. The aim was to study the causes and mechanisms that lead to chronic inflammatory diseases. To this end the children have been sampled extensively since birth for multi-omics analyses, along with records of early-life exposures and clinical assessments. Such clinical data is associated with the omics data with the goal of uncovering unknown disease mechanisms for common childhood diseases. The age 1 year faecal virome study made available here is part of that effort, and was performed as part of the EarlyVir project (http://copsac.com/EarlyVir) funded by JPI-HDHL. The reads have been assembled and an exhaustive taxonomy for all known and novel DNA viruses in the samples has been made available here: http://copsac.com/earlyvir/f1y/fig1.svg . Most DNA viruses in the samples were bacteriophages, although human viruses also made up a substantial portion. Most bacteriophages belonged to novel families and were temperate rather than virulent.