Optimal parameter set.

“Best” parameter set found by our optimization scheme: The Hill coefficients and are unit-less positive real numbers. , , , and are rate constants for splicing and translation in units . The activation and Michaelis constants in units of concentrations are , , , , , and . The maximal transcription and degradation rates , , , , , and have units of concentration per hour. The alternative splicing coefficients , , , and are given in units of the inverse of concentration times hour. As we cannot deduce explicit single cell concentration values from the experimental time traces used here, concentration values are given in arbitrary units ([a.u.]) rather than in some hypothetically defined absolute units.