Divergent Synthesis of 2‑Aminofurans via Palladium-Catalyzed Acetoxylative, Alkoxylative, and Hydroxylative Cycloisomerization of Homoallenyl Amides

A fine-tunable transformation, including Pd-catalyzed acetoxylative, alkoxylative, and hydroxylative cycloisomerization of homoallenyl amides, has been realized with hypervalent iodine organic compounds as the oxidants, giving polysubstituted 2-aminofurans in promising yields at room temperature. The selective formation of three different types of products from the same starting materials makes this reaction particularly attractive and useful for organic synthesis.