Multi-omics study of DBD-a4 helix of EWS::FLI in TTC466 cells

NIAID Data Ecosystem2026-05-02 收录

尤文肉瘤转录调控

EWS::FLI融合蛋白功能

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1116744 数据链接链接失效反馈

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资源简介：

Multi-omics study of DBD-a4 helix of EWS::FLI to understand the underlying mechanism of transcriptional regulation in Ewing sarcoma cell line: TTC466

创建时间：

2024-05-26

Research of EGR2 binding sites in Ewing cell line by CHIP-seq experiment

尤文肉瘤转录调控

ChIP-seq分析

Identification of EGR2 binding site, H3K27Ac, H3K4me3 and EWSR1-FLI1 in Ewing cell line POE shEGR2_4#22 clone harboring a doxycycline-inducible shRNA against EGR2 overexpressed HA-EGR2

NIAID Data Ecosystem80

EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma (RNA-Seq)

尤文肉瘤转录调控

染色质重编程

Ewing sarcoma is a prototypical fusion transcription factor-associated pediatric cancer that expresses EWS/FLI or highly related fusions. EWS/FLI dysregulates transcription to induce and maintain sarc

NIAID Data Ecosystem40

EWS-FLI1-regulated Core Transcriptional Regulatory Circuit promotes Ewing sarcoma progression

尤文肉瘤转录调控

超级增强子回路

We identify and validate an Ewing sarcoma-specific CRC, which is under control of EWS-FLI1. Formed by KLF15, TCF4 and NKX2-2, this CRC apparatus coordinates the gene expression programs in Ewing sarco

NIAID Data Ecosystem30

The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct from its DNA-binding function in Ewing sarcoma [RNA-seq III]. The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct from its DNA-binding function in Ewing sarcoma [RNA-seq III]

尤文肉瘤转录调控

RNA-seq分析

The purpose of this study was to determine transcriptional regulatory activity of EWS/FLI mutants in an alternative, non-Ewing sarcoma cell line. EWS/FLI cDNA constructs including various deletions of

NIAID Data Ecosystem40

RNA-seq data of knowk-down of STAG2 or EWSR1-FLI1 in Ewing sarcoma cell lines (siCT, siEF1 & siSA2)

尤文肉瘤转录调控

STAG2基因

STAG2, a member of cohesin, is one of the most recurrently mutated genes in human cancer. Here, we investigated STAG2 function in the context of Ewing sarcoma, an aggressive bone tumor driven by EWS-F

NIAID Data Ecosystem40

Multi-omics study of DBD-a4 helix of EWS::FLI in TTC466 cells

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