Indirubin-3'-aminooxy-acetate inhibits glycogen phosphorylase by binding at the inhibitor and the allosteric site. Broad specificities of the two sites

Indirubin-3'-aminooxy-acetate inhibits glycogen phosphorylase by binding at the inhibitor and the allosteric site. Broad specificities of the two sites Descriptor: ({[(3E)-2'-OXO-2',7'-DIHYDRO-2,3'-BIINDOL-3(7H)-YLIDENE]AMINO}OXY)ACETIC ACID, Glycogen phosphorylase, muscle form, ... Authors: Kosmopoulou, M.N, Leonidas, D.D, Chrysina, E.D, Eisenbrand, G, Oikonomakos, N.G. Deposit date: 2005-03-21 Release date: 2006-03-07 Last modified: 2025-03-26 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Indirubin-3'-Aminooxy-Acetate Inhibits Glycogen Phosphorylase by Binding at the Inhibitor and the Allosteric Site. Broad Specificities of the Two Sites LETT.DRUG DES.DISCOVERY, 2, 2005

靛玉红-3'-氨基氧基乙酸（Indirubin-3'-aminooxy-acetate）可通过结合抑制剂位点与别构位点（allosteric site）实现对糖原磷酸化酶（glycogen phosphorylase）的抑制，两类位点均具有广谱特异性。
描述符：({[(3E)-2'-氧代-2',7'-二氢-2,3'-双吲哚-3(7H)-亚基]氨基}氧基)乙酸（({[(3E)-2'-OXO-2',7'-DIHYDRO-2,3'-BIINDOL-3(7H)-YLIDENE]AMINO}OXY)ACETIC ACID）、糖原磷酸化酶肌肉型（Glycogen phosphorylase, muscle form）……
作者：Kosmopoulou, M.N.、Leonidas, D.D.、Chrysina, E.D.、Eisenbrand, G.、Oikonomakos, N.G.
入库日期：2005-03-21
发布日期：2006-03-07
最后修改日期：2025-03-26
实验方法：X射线衍射法（分辨率1.9 Å）
引用文献：靛玉红-3'-氨基氧基乙酸通过结合抑制剂位点与别构位点抑制糖原磷酸化酶：两类位点的广谱特异性，《药物设计与发现通讯》（LETT.DRUG DES.DISCOVERY），第2卷，2005年