Extracellular Matrix Plays a Crucial Role in Postoperative Angiogenesis in Moyamoya Disease

Indirect revascularization is an effective treatment for moyamoya disease (MMD), but the surgery effect depends on the collateral vessel formation. This study aimed to explore the molecular mechanisms driving angiogenesis in the temporal muscle post-surgery. This study utilized a single-center, prospectively sampled, retrospective cohort design. Temporal muscle tissue was collected, and a comprehensive transcriptome-wide analysis was subsequently conducted. Participants were categorized into Good (Grade A, n=13) and Poor (Grade C, n=12) groups based on Matsushima grading.This transcriptomic study emphasized the centrality of collagen as the underlying molecular mechanisms that facilitate angiogenesis. In addition, it revealed the significant contributions of the NADH dehydrogenase (complex I) family and fat cell proliferation in this process.