M. thermoresistible GuaB2 delta-CBS in complex with inhibitor Compound 35 (VCC620637)

M. thermoresistible GuaB2 delta-CBS in complex with inhibitor Compound 35 (VCC620637) Descriptor: 2-(4-fluorophenyl)-1-{4-[(isoquinolin-5-yl)sulfonyl]piperazin-1-yl}ethan-1-one, INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase Authors: Ascher, D.B, Pacitto, A, Blundell, T.L. Deposit date: 2018-04-18 Release date: 2019-05-01 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Synthesis and Structure-Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH. Eur.J.Med.Chem., 174, 2019耐热型M. thermoresistible的GuaB2 ΔCBS与抑制剂Compound 35（VCC620637）的复合物 表征物：2-(4-氟苯基)-1-{4-[(异喹啉-5-基)磺酰基]哌嗪-1-基}乙-1-酮、肌苷酸（INOSINIC ACID）、肌苷-5'-单磷酸脱氢酶（Inosine-5'-monophosphate dehydrogenase）、肌苷-5'-单磷酸脱氢酶 作者：Ascher D.B.、Pacitto A.、Blundell T.L. 保藏日期：2018-04-18 发布日期：2019-05-01 最后修改日期：2023-10-04 实验方法：X射线衍射（1.8 Å） 引用文献：《1-(5-异喹啉磺酰基)哌嗪类衍生物作为结核分枝杆菌IMPDH抑制剂的合成与构效关系》，《Eur.J.Med.Chem.》，174卷，2019年