Genome-wide transcriptome analysis of Esrrb WT and conditional Esrrb KO mouse embryonic stem cells

We report the application of genome-wide RNA-sequencing analysis for Esrrb WT and conditional Esrrb KO mES cells after differentation for 48 hours. Global transcriptome profiling revealed impaired induction of formative genes in conditional KO cells compared to WT cells. Comparative gene expression profiling analysis of RNA-seq data for E14 and Esrrb KO cells stably transfected either with an inducible Empty vector or with an inducible vector expressing Esrrb. Cells were maintained with DOX and 2iL and subsequently differentiated for 48 hours in absence of 2iL and DOX.