Investigation into whether the RD2 element in serotype M28 isolates of group A Streptococcus influences global gene expression. Investigation into whether the RD2 element in serotype M28 isolates of group A Streptococcus influences global gene expression

We used RNA-Seq to compare a parental M28 isolate with an isogenic mutant in which the RD2 element had been deleted. Overall design: Parental M28 isolate MGAS6180 and an RD2 deletion mutant derivative (M28ΔRD2) were compared following growth in THY broth to the exponential phase of growth (an O.D.600 of 0.5).