Multivariable model for disease-free survival in the discovery and validation cohorts.

The multivariable model contained location, stage and MSI status in addition to the ERCC5 His46His, OGG1 Ser326Cys, ERCC5 Asn118Asn, TYMS indel 6 bp, and GSTM1 gene deletion genotypes in the discovery cohort and the ERCC5 His46His and GSTM1 gene deletion genotypes in the validation cohort as covariates. The genotypes for the OGG1 Ser326Cys, ERCC5 Asn118Asn, and TYMS indel 6 bp polymorphisms were not available in the validation cohort. CI: confidence interval, HR: hazard ratio, n: number of patients, nd: not done, vs: versus. Event refers to recurrence, metastasis or death in the patient, whichever had occurred earlier.#The referent categories are underlined. Please note that reflecting the small numbers of patients in the validation cohort, the CIs for the effect estimate in stage IV patients are quite wide and should not be interpreted as an accurate estimation.