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Adenosine A2A antagonists and their affinity for the receptor: in vitro binding.

Figshare2015-12-02 更新2026-04-29 收录

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https://figshare.com/articles/dataset/_Adenosine_A_2A_antagonists_and_their_affinity_for_the_receptor_in_vitro_binding_/1272227 数据链接链接失效反馈

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aKi is expressed in nM (rat or human).ND: no data available.Adenosine A2A antagonists and their affinity for the receptor: in vitro binding.

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2015-12-02

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We expanded on a series of pyrido[2,1-f]purine-2,4-dione derivatives as human adenosine A3 receptor (hA3R) antagonists to determine their kinetic profiles and affinities. Many compounds showed high

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Regio- and Stereoselective Ribose Modification in Truncated 2,8-Disubstituted Adenosine Scaffold to Develop Highly Potent A2A Adenosine Receptor Antagonists

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Previous molecular dynamics simulations of hA2AAR with 2b and structure–activity relationship (SAR) analyses prompted us to synthesize diol-, deoxy-, fluoro-, and methoxy-derivatives (4) in a regio- a

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Structure of the A2A-StaR2-bRIL562-Compound 4e complex at 1.9A obtained from bespoke co-crystallisation experiments.

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Structure of the A2A-StaR2-bRIL562-Compound 4e complex at 1.9A obtained from bespoke co-crystallisation experiments. Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-(3-amino-5-phenyl-1,2

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Design, Synthesis, and Pharmacological Characterization of 2‑(2-Furanyl)thiazolo[5,4‑d]pyrimidine-5,7-diamine Derivatives: New Highly Potent A2A Adenosine Receptor Inverse Agonists with Antinociceptive Activity

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In this study, we describe the design and synthesis of new N5-substituted-2-(2-furanyl) thiazolo[5,4-d]pyrimidine-5,7-diamines (2–18) and their pharmacological characterization as A2A adenosine rece

Figshare2016-11-29 更新30

Adenosine A2A antagonists and their affinity for the receptor: in vitro binding.

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