Data from: Association between dietary magnesium intake and hyperuricemia

Objective: To examine the cross-sectional associations between dietary magnesium (Mg) intake and hyperuricemia (HU). Methods: 5168 subjects were included in this study. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire. Hyperuricemia (HU) was defined as uric acid ≥ 416 mmol/L for male population and ≥ 360 mmol/L for female. A multivariable logistic analysis model was applied to test the associations after adjusting a number of potential confounding factors. Results: The relative odds of the overall prevalence of HU were decreased by 0.57 times in the fourth quintile of Mg intake (OR 0.57, 95% CI 0.35-0.94) and 0.55 times in the fifth quintile (OR 0.55, 95% CI 0.30-1.01) comparing with the lowest quintile, and P for trend was 0.091. The results of multivariable linear regression also suggested a significant inverse association between serum uric acid and Mg intake (β=-0.028, P=0.022). For male, the relative odds of HU were decreased by 0.62 times in the third quintile of Mg intake (OR 0.62, 95% CI 0.40-0.97), 0.40 times in the fourth quintile (OR 0.40, 95% CI 0.23-0.72) and 0.35 times in the fifth quintile (OR 0.35, 95% CI 0.17-0.71) comparing with the lowest quintile, and P for trend was 0.006. Multivariable adjusted inverse association was also existed between serum uric acid and Mg intake in male population (β=-0.061, P=0.002). However, no significant association was observed between dietary Mg intake and HU for female. Conclusions: The findings of this cross-sectional study indicated that dietary Mg intake is inversely associated with HU, independent of some major confounding factors. In addition, this association remains valid for the male subgroup, but not for the female subgroup. Level of Evidence: LevelⅢ, cross-sectional study.研究目的：探讨膳食镁（Magnesium，Mg）摄入与高尿酸血症（Hyperuricemia，HU）之间的横断面关联。研究方法：本研究共纳入5168名研究对象，采用经过验证的半定量食物频率问卷（semi-quantitative food frequency questionnaire）评估膳食摄入情况。高尿酸血症的判定标准为：男性人群血尿酸≥416 mmol/L，女性人群血尿酸≥360 mmol/L。在校正一系列潜在混杂因素后，采用多变量logistic回归分析模型检验二者的关联。研究结果：与最低五分位组相比，膳食镁摄入第四五分位组的总体高尿酸血症相对发病风险降低了0.57倍（OR=0.57，95%CI：0.35~0.94），第五五分位组降低了0.55倍（OR=0.55，95%CI：0.30~1.01），趋势检验P值为0.091。多变量线性回归分析结果同样显示，血清尿酸水平与膳食镁摄入呈显著负相关（β=-0.028，P=0.022）。针对男性亚组的分析显示，与最低五分位组相比，第三五分位组的高尿酸血症相对发病风险降低了0.62倍（OR=0.62，95%CI：0.40~0.97），第四五分位组降低了0.40倍（OR=0.40，95%CI：0.23~0.72），第五五分位组降低了0.35倍（OR=0.35，95%CI：0.17~0.71），趋势检验P值为0.006。男性亚组中，经多变量校正后，血清尿酸水平与膳食镁摄入仍存在显著负相关关系（β=-0.061，P=0.002）。然而，女性亚组中未观察到膳食镁摄入与高尿酸血症存在显著关联。研究结论：本横断面研究结果表明，膳食镁摄入与高尿酸血症呈负相关，且不受部分主要混杂因素的影响。此外，该关联在男性亚组中依然成立，但在女性亚组中未观察到显著关联。证据等级：Ⅲ级，横断面研究。