Cryo-EM structure of the Strand displacement Complex (III) of Yeast Mitochondrial DNA polymerase Gamma (MIP1) with downstream DNA

Cryo-EM structure of the Strand displacement Complex (III) of Yeast Mitochondrial DNA polymerase Gamma (MIP1) with downstream DNA Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, DNA polymerase gamma, ... Authors: Nayak, A.R, Sokolova, V.O, Sillamaa, S, Sedmen, J, Temiakov, D. Deposit date: 2024-08-08 Release date: 2025-03-19 Last modified: 2025-03-26 Method: ELECTRON MICROSCOPY (2.96 Å) Cite: Structural basis for intrinsic strand displacement activity of mitochondrial DNA polymerase. Nat Commun, 16, 2025

本数据集为酵母线粒体DNA聚合酶γ（DNA polymerase gamma，MIP1）的链置换复合物III（Strand displacement Complex (III)）与下游DNA结合的冷冻电镜（Cryo-EM）结构，该复合物的配体包括2'-脱氧腺苷5'-三磷酸、3'-脱氧胸苷5'-单磷酸、DNA聚合酶γ等。作者：Nayak, A.R、Sokolova, V.O、Sillamaa, S、Sedmen, J、Temiakov, D。提交日期：2024-08-08，发布日期：2025-03-19，最后修改日期：2025-03-26。实验方法：电子显微镜（分辨率2.96埃）。引用文献：《线粒体DNA聚合酶固有链置换活性的结构基础》，《自然·通讯》（Nat Commun），第16卷，2025年。