Inhibitory activity of the diphosphate metabolites of adefovir, tenofovir, and PMEO-DAPym against HIV-1 RT.
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a50% Inhibitory concentration (drug metabolite concentration required to inhibit HIV-1 RT-catalysed DNA polymerization by 50%), using dATP (3.2 µM) as the competing substrate and poly rU.dA as the primer/template.
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2015-12-02
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