EGFR Exon20 insertion mutant SVD bound with (S)-3-((3-chloro-2-methoxyphenyl)amino)-2-(3-((tetrahydrofuran-2-yl)methoxy)pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

EGFR Exon20 insertion mutant SVD bound with (S)-3-((3-chloro-2-methoxyphenyl)amino)-2-(3-((tetrahydrofuran-2-yl)methoxy)pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one Descriptor: 1,2-ETHANEDIOL, 3-[(3-chloranyl-2-methoxy-phenyl)amino]-2-[3-[[(2S)-oxolan-2-yl]methoxy]pyridin-4-yl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one, Epidermal growth factor receptor, ... Authors: Hilbert, B.J, Brooijmans, N, Pagliarini, R.A, Milgram, B.C. Deposit date: 2024-08-29 Release date: 2025-05-14 Last modified: 2025-07-23 Method: X-RAY DIFFRACTION (1.68 Å) Cite: STX-721, a Covalent EGFR/HER2 Exon 20 Inhibitor, Utilizes Exon 20-Mutant Dynamic Protein States and Achieves Unique Mutant Selectivity Across Human Cancer Models. Clin.Cancer Res., 31, 2025

表皮生长因子受体（EGFR）外显子20插入突变体SVD与(S)-3-((3-氯-2-甲氧基苯基)氨基)-2-(3-((四氢呋喃-2-基)甲氧基)吡啶-4-基)-1,5,6,7-四氢-4H-吡咯并[3,2-c]吡啶-4-酮结合的复合物。描述符：1,2-乙二醇、3-[(3-氯-2-甲氧基苯基)氨基]-2-[3-[[(2S)-四氢呋喃-2-基]甲氧基]吡啶-4-基]-1,5,6,7-四氢吡咯并[3,2-c]吡啶-4-酮、表皮生长因子受体（Epidermal growth factor receptor）……。作者：Hilbert B.J.、Brooijmans N.、Pagliarini R.A.、Milgram B.C.。存入日期：2024-08-29；发布日期：2025-05-14；最后修改日期：2025-07-23。实验方法：X射线衍射（1.68埃）。引用文献：《STX-721：一种共价EGFR/HER2外显子20抑制剂，利用外显子20突变体的动态蛋白构象并在人类癌症模型中实现独特的突变体选择性》，《临床癌症研究》（Clin.Cancer Res.），第31卷，2025年