Development of an improved inhibitor of Lats Kinases to promote regeneration of mammalian organs. Development of an improved inhibitor of Lats Kinases to promote regeneration of mammalian organs

To confirm that treatment with TDI‑011536 activates Yap in vivo, we collected liver and heart tissue for RNA sequencing four hours after IP injection at 200 mg/kg Overall design: Three control mice and three experimental mice were used for the study. Each one was IP injected with 200mg/kg of LKI-2, and after four hours, liver and hearts were collected for RNA extraction and sequencing.