Cell type distribution in female and male mouse brains / SERT_GFP_M4_200104

This project proposes to establish an Anatomical Collaboratory for Systematic Atlasing of Cell-Type Distribution and Morphology in female and male brain. This Collaboratory will apply standardized, unbiased and largely automated methods developed in the group’s laboratories to atlas the distribution and morphology of >80 molecularly defined cell classes and cell type across all regions of the female and male brain. This work will yield the most comprehensive characterization of cell type anatomy in the mammalian brain to date, establishing a structural basis for building an integrated Cell Type Brain Atlas.

本项研究旨在构建一个针对雌性和雄性大脑中细胞类型分布与形态的系统化图谱解剖协同实验室。该协同实验室将采用实验室研发的标准化、无偏见且高度自动化的方法，对超过80种分子定义的细胞类型及其形态在大脑所有区域进行图谱绘制。此项研究将提供迄今为止对哺乳动物大脑中细胞类型解剖的最为全面的描述，并为构建一个综合性的细胞类型大脑图谱奠定结构基础。