nsp3 binds to nsp7-8 and nsp12-16

This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.<br><br>On the final assembly, proteomics data suggest that the NAB−βSM−TM1 domains of nsp3 can interact with nsp7 − 8, as well as nsps 12–16, and the domain Y1 plus CoV-Y interacts with nsp9 and nsp12 (Imbert et al., 2008). Also a PL2pro−NAB−βSM−TM1 construct of Nsp3 can bind Nsp4 and Nsp12, while the region from TM1 to the end of Nsp3 only binds Nsp8 (Pan et al., 2008).

本次 COVID-19 事件是由 SARS-CoV-1 数据的计算机推理（详见 https://reactome.org/documentation/inferred-events）与人工编纂相结合而成，具体编纂过程详述于 SARS-CoV-2 感染途径的总结中。<br><br>在最终汇编过程中，蛋白质组学数据表明，nsp3 的 NAB−βSM−TM1 结构域可与 nsp7 − 8 以及 nsps 12–16 发生相互作用，同时结构域 Y1 以及 CoV-Y 与 nsp9 和 nsp12 相互作用（参见 Imbert 等人，2008 年的研究）。此外，Nsp3 的 PL2pro−NAB−βSM−TM1 构建体能够与 Nsp4 和 Nsp12 结合，而 nsp3 从 TM1 至终端的区域仅与 Nsp8 结合（参见 Pan 等人，2008 年的研究）。