Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor

Protein Data Bank Japan2023-09-27 更新2026-03-21 收录

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Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor Descriptor: (6S)-1,3,4,5-tetra-O-acetyl-2,6-anhydro-6-{[5-(sulfamoyloxy)pentyl]sulfamoyl}-L-altritol, Carbonic anhydrase 2, GLYCEROL, ... Authors: Mahon, B.P, Lomelino, C.L, Driscoll, J.M, McKenna, R. Deposit date: 2015-05-19 Release date: 2015-08-05 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates. J.Med.Chem., 58, 2015

人类碳酸酐酶II（Human Carbonic Anhydrase II）与葡萄糖基磺酰胺酸酯抑制剂形成的复合物描述符：(6S)-1,3,4,5-四-O-乙酰基-2,6-脱水-6-{[5-(磺酰氧基)戊基]磺酰基}-L-阿卓糖醇（(6S)-1,3,4,5-tetra-O-acetyl-2,6-anhydro-6-{[5-(sulfamoyloxy)pentyl]sulfamoyl}-L-altritol）、碳酸酐酶2（Carbonic anhydrase 2）、甘油（GLYCEROL）等作者：Mahon, B.P.、Lomelino, C.L.、Driscoll, J.M.、McKenna, R. 提交日期：2015-05-19 发布日期：2015-08-05 最后修改日期：2023-09-27 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.5埃（Å）引用文献：《利用葡萄糖基磺酰胺酸酯类化合物的构效关系研究癌症相关碳酸酐酶IX的选择性抑制作用》（Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates），《J.Med.Chem.》，58卷，2015年

创建时间：

2015-05-19