Dataset for the project "LRRK2 as a novel pharmacological target for treatment of neurodegenerative diseases" (GR-2016-02362548)

Dataset for the project "LRRK2 as a novel pharmacological target for treatment of neurodegenerative diseases" (GR-2016-02362548). <strong>Aim 1:</strong> Understanding whether LRRK2 mediates neuroinflammation triggered by PD and AD misfolded proteins using in vitro and in vivo models. <strong>Aim 2:</strong> Exploring whether and how LRRK2-related neuroinflammation affects hiPSC-derived neuronal function. <strong>Aim 3:</strong> Exploring whether hiPSC-derived neurons carrying LRRK2 mutation/variant are more vulnerable to neuroinflammation. The present dataset contains the following folders: <strong>1- Aim 1</strong> - In vitro - Attivazione infiammazione - Generazione proteina amiloide - LRRK2 infiammazione - In vivo - Generazione proteina amiloidi - Infiammazione abeta - Infiammazione asyn - Microglia-Astrociti abeta - Microglia-Astrociti asyn <strong>2- Aim 2</strong> - hiPSC Col RNASeq - hiPSC DA RNASEq - Neuroni colinergici - Neuroni dopaminergici <strong>3- Aim 3</strong> - Gentotyping human cells