Influenza A/H7N9 polymerase in replicase-like conformation in pre-initiation state with Pol II pS5 CTD peptide mimic bound in site 1A/2A

Influenza A/H7N9 polymerase in replicase-like conformation in pre-initiation state with Pol II pS5 CTD peptide mimic bound in site 1A/2A Descriptor: 51-mer vRNA loop (v51_mut_S), MAGNESIUM ION, Polymerase acidic protein, ... Authors: Arragain, B, Cusack, S. Deposit date: 2023-06-27 Release date: 2024-02-21 Last modified: 2024-10-23 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024核心描述：结合有丝氨酸5磷酸化的RNA聚合酶II（Pol II）羧基末端结构域（CTD）肽模拟物、处于预起始状态且呈类复制酶构象的甲型流感病毒A/H7N9聚合酶。数据集描述：51聚体病毒RNA环（v51_mut_S）、镁离子、聚合酶酸性蛋白…… 作者：B. Arragain、S. Cusack。提交日期：2023-06-27；发布日期：2024-02-21；最后修改日期：2024-10-23。实验方法：电子显微镜（2.9 Å）。引用文献：宿主RNA聚合酶II羧基末端结构域是流感病毒基因组复制的锚定位点。《自然·通讯》，15，2024