Identify signature genes associated with nanoparticle carrying IRF5 mRNA treatment in bone marrow derrived macrophages

To identify signature genes associated with nanoparticles carrying IRF5 mRNA treatment on primary macrophages, we analyzed 770 genes in 19 different pathways and processes across 7 different myeloid cell types. In the study presented here, we performed genome analysis on (1) M2-like(preincubated with IL4) and (2) M1-like macrophage standards (preincubated with MPLA), (3) IRF5-NPs and (4) eGFP-NPs treated M2-like macrophages,