Proteomic analysis of sweat samples from tuberculosis patients

We performed a global proteomic profile of eccrine sweat sampled from patients with active pulmonary TB, other lung diseases (non-TB disease), and healthy controls. A comparison of proteomics results between Active-TB, Non-TB and Healthy Controls was done in search for proteins unique to the active TB-patient cohort as well as proteins unique to those without TB disease. We conclude tthat global proteomic profiling of eccrine sweat collected from TB and non-TB patients is a viable approach for the identification of unique proteins differentially present based on clinical cohort. These proteins may represent unique biomarker profiles that upon further verification and validation could be used to develop a non-sputum based test for diagnosis of active TB.