Benchmark results for comparative modeling of G-protein coupled receptors.

Full receptor, transmembrane region and extracellular loop two RMSD over C-alpha atoms compared to the experimental structure is reported for models in each category.aTop ranked model is determined by the lowest energy model from the largest cluster.bECL2 of A2Ar and H1R could not be evaluated because of unresolved structure in this region of the experimental structure in the Protein Data Bank.cECL2b represents the C-terminal half of ECL2, after the disulfide bond, which contains the residues that contribute to ligand binding as represented in the experimental structures from the PDB.