PfalDB
收藏资源简介：
Plasmodium falciparum is one of the deadliest protozoan parasite species among those that cause malaria. Uncontrolled use of antimalarial drugs has resulted in evolutionary selection pressure favoring high levels of resistance to antimalarials; currently P.falciparum shows resistance to all classes of antimalarials. Therefore it is essential to identify novel drug targets, and design selective anti-malarials which can overcome resistance. While many drug targets are freely available in various public domain resources, a single comprehensive source of data containing easily searchable and retrievable information is currently lacking. To facilitate the total integration and mining of data emerging from different drug consortia and also to prioritize drug targets for structure-based drug design, an open-access, inclusive comprehensive database for Plasmodium falciparum was established. Meta data of known/modeled structures along with binding site parameters of drug targets have been included in the database. Additionally, chemical compounds showing a positive inhibitory assay against Plasmodium falciparum or known drug targets have also been provided. The database is accessible at http://pfaldb.jnu.ac.in. The database provides diverse information regarding the structure, sequence, stage specific gene expression, pathway, action mechanism, essentiality and druggability for each drug target, and literature to assess the validation status of individual drug targets. It also includes information on individual anti-malarials with their activity and bioassay.
恶性疟原虫(Plasmodium falciparum)是引发疟疾的原生动物寄生虫中致死性最强的物种之一。抗疟药物的无节制使用已产生进化选择压力，促使该寄生虫对各类抗疟药物产生高水平耐药性；目前恶性疟原虫已对所有类别抗疟药物均表现出耐药性。因此，鉴定新型药物靶点并设计可克服耐药性的选择性抗疟药物显得尤为关键。尽管诸多药物靶点可从各类公共领域资源中免费获取，但目前仍缺乏一个可便捷检索、提取信息的综合型单一数据来源。为推动不同药物联盟产生的数据的全面整合与挖掘，同时为基于结构的药物设计排序药物靶点优先级，研究人员构建了一个面向恶性疟原虫的开放获取、包容性综合数据库。该数据库收录了已知/建模结构的元数据，以及药物靶点的结合位点参数。此外，数据库还提供了对恶性疟原虫或已知药物靶点表现出阳性抑制活性的化学化合物信息。该数据库的访问地址为http://pfaldb.jnu.ac.in。该数据库为每个药物靶点提供多维度信息，涵盖结构、序列、阶段特异性基因表达、通路、作用机制、必需性与成药性，同时收录用于评估单个药物靶点验证状态的相关文献。此外，数据库还收录了各类抗疟药物的活性及生物测定相关信息。
