Interactions of high sPD-1 with high HBV viral load and copresence of these two risk factors with genotype C HBV in risks for HCC and liver cirrhosis.

aORs and 95% CIs were mutually adjusted for age (continuous variable), cigarette smoking (yes or no), alcohol consumption (yes or no), first-degree family history of HCC (yes or no), and BMI (≥25 or <25 kg/m2).
b84 subjects with missing data on ultrasonography measurement of liver during follow-up were excluded from analysis.
c33 subjects (2 HCC cases and 31 non-HCC subjects) with missing data on HBV genotype were excluded from analysis.
d113 subjects were excluded due to missing data on follow-up ultrasonography measurement of liver and/or HBV genotype (80 were missing on follow-up ultrasonography measurement alone; 29 were missing on HBV genotype alone; 4 were missing on both variables).
AP, attributable proportion due to interaction; CI, confidence interval; HCC, hepatocellular carcinoma; LC, liver cirrhosis; OR, odds ratios; RERI, relative excess risk due to interaction.
Interactions of high sPD-1 with high HBV viral load and copresence of these two risk factors with genotype C HBV in risks for HCC and liver cirrhosis.