p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2

Phosphorylated JAK1 (p-Y-JAK1) phosphorylates the STAT proteins STAT1 (Tian et al. 1994, Tian et al. 1996, Shimoda et al. 1997, also inferred from mouse homologs), STAT3 (Tian et al. 1994, Tian et al. 1996, Shimoda et al. 1997, Ward et al. 1999, Marino and Roguin 2008, Kumar et al. 2014, also inferred from mouse homologs), and STAT5 (Tian et al. 1994, Tian et al. 1996, Shimoda et al. 1997, also inferred from mouse homologs) at the cytosolic domain of CSF3R (G-CSFR). Phosphorylated JAK2 acts redundantly with p-Y-JAK1 to phosphorylate STAT proteins (Kumar et al. 2014, also inferred from mouse homologs).

磷酸化型JAK1（p-Y-JAK1）在CSF3R（G-CSFR）的细胞质域中磷酸化STAT蛋白，包括STAT1（Tian等，1994，Tian等，1996，Shimoda等，1997，亦从小鼠同源物推断而来）、STAT3（Tian等，1994，Tian等，1996，Shimoda等，1997，Ward等，1999，Marino和Roguin，2008，Kumar等，2014，亦从小鼠同源物推断而来）以及STAT5（Tian等，1994，Tian等，1996，Shimoda等，1997，亦从小鼠同源物推断而来）。磷酸化型JAK2与p-Y-JAK1协同作用，共同磷酸化STAT蛋白（Kumar等，2014，亦从小鼠同源物推断而来）。