PopAlign_Data

This file contains single-cell RNA-seq datasets associated with : Chen, S, et al. 2020. “Dissecting Heterogeneous Cell Populations across Drug and Disease Conditions with PopAlign.” bioRxiv. https://doi.org/10.1101/421354. ------------------------ DATASETS ------------------------ Each data folder includes:barcodes.tsv : cell barcodes genes.tsv : genes[ Name ].mtx : sparse matrix file of transcript counts Subfolders MM1-MM4:---------------22,294 Peripheral Blood Mononuclear Cells (PBMCs) from four multiple myeloma patients.Data collected using 10x 3' Gene Expression v2 kit. healthy1/healthy2: ------------------------- 12,865 PBMCs from two healthy donors. Data collected using 10x 3' Gene Expression v2 kit. drugscreen: --------------- 33,482 cells40 drugs applied at 1uM for 24 hours onto PBMCs collected from a single healthy donor. Data collected using 10x 3' Gene Expression v3 kit. Includes a metadata file (meta.csv) with each row corresponding to each cell in the gene expression matrix. Drugs tested:Meprednisone, Dexrazoxane HCl (ICRF-187, ADR-529), Etodolac, Phenylbutazone, Pomalidomide, Budesonide, Loteprednol etabonate, CTRL, Betamethasone Valerate, Febuxostat, Sulfasalazine, Flurbiprofen, Mianserin HCl, Naproxen Sodium, Triamcinolone Acetonide, Acetylcysteine, Everolimus (RAD001), Isotretinoin, Ibuprofen, Doramapimod (BIRB 796), Allopurinol Sodium, Tranilast, Cyclosporine, Adapalene, Thalidomide, Celecoxib, Ketoprofen, Loratadine, Tazarotene, Bimatoprost, Cetirizine DiHCl, Mesalamine, Mercaptopurine (6-MP), Busulfan, Zafirlukast, Zileuton, Latrepirdine 2HCl, Rapamycin (Sirolimus), Alprostadil, Masitinib (AB1010), Methotrexate