Relative density of nonsynonymous variants (<i>rdnsv</i>).

Candidate genes for the nervous system (NSG) and the immune system (ISG) are defined by tissue specific expression or keyword search and further compared with a set of randomly sampled genes (RSG). A) Overall rdnsv estimates for a diploid genome and 200 exome sequences, which reflect the density of nonsynonymous variants on a mixture of SNVs that range from rare to common in their population frequency. B) SNVs from the 200 exome dataset are additionally stratified by their derived allele frequency and a regression model is fitted to the values of rdnsv. The predicted value for the allele frequency of 0 is referred to as rdnsv0, whereas the predicted value for the allele frequency of 1 is referred to as rdnsv1. The interval in brackets shows the 2.5% and 97.5% quantiles from 10.000 random draws of genes.