Malvidin modulated gut microbial dysbiosis in a murine colitis model induced by dextran sulfate sodium

The effect of MV on the structure and function of the colon microbiome was evaluated using 16S rRNA gene sequencing and a Random-Matrix Theory based network algorithm. DSS had a profound effect on the gut microbiome and significantly repressed both microbial richness and evenness, MV further reduced evenness but promoted microbial interactions and restored the Firmicutes to Bacteroidetes ratio repressed by DSS. Moreover, MV reduced the incident of pathogenic bacteria, such as Ruminococcus gnavus, in colitis mice.