Bovine GRK2 in complex with Gbetagamma subunits and CCG224406
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Bovine GRK2 in complex with Gbetagamma subunits and CCG224406 Descriptor: (4~{S})-4-[3-[(2,6-dimethoxyphenyl)methylcarbamoyl]-4-fluoranyl-phenyl]-~{N}-(1~{H}-indazol-5-yl)-6-methyl-2-oxidanylidene-3,4-dihydro-1~{H}-pyrimidine-5-carboxamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Cato, M.C, Waninger-Saroni, J, Tesmer, J.J.G. Deposit date: 2016-01-05 Release date: 2016-05-11 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.79 Å) Cite: Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors. J.Med.Chem., 59, 2016
结合Gβγ亚基（Gbetagamma subunits）与CCG224406的牛源G蛋白偶联受体激酶2（GRK2）
描述：(4S)-4-[3-[(2,6-二甲氧基苯基)甲基氨基甲酰基]-4-氟苯基]-N-(1H-吲唑-5-基)-6-甲基-2-氧代-3,4-二氢-1H-嘧啶-5-甲酰胺、β肾上腺素能受体激酶1（β-adrenergic receptor kinase 1）、鸟嘌呤核苷酸结合蛋白G(I)/G(S)/G(O)亚基γ-2（Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2）等
作者：Cato, M.C、Waninger-Saroni, J、Tesmer, J.J.G.
存入日期：2016-01-05
发布日期：2016-05-11
最后修改日期：2024-03-06
实验方法：X射线衍射（分辨率2.79 Å）
引用文献：《高选择性强效G蛋白偶联受体激酶2抑制剂的基于结构设计、合成及生物学评价》，J.Med.Chem., 59, 2016
创建时间：
2016-01-05
