Stereoselective Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Lactam Based HIV-1 Protease Inhibitors
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Stereoselective Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Lactam Based HIV-1 Protease Inhibitors Descriptor: METHYL ((S)-1-(2-(3-((3S,4S)-3-BENZYL-4-HYDROXY-1-((1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL)-2-OXOPYRROLIDIN-3-YL)PROPYL)-2-(4-(PYRIDIN-4-YL)BENZYL)HYDRAZINYL)-3,3-DIMETHYL-1-OXOBUTAN-2-YL)CARBAMATE, POL PROTEIN Authors: Wu, X, Ohrngren, P, Joshi, A.A, Trejos, A, Persson, M, Unge, J, Arvela, R.K, Wallberg, H, Vrang, L, Rosenquist, A, Samuelsson, B.B, Unge, J, Larhed, M. Deposit date: 2011-11-01 Release date: 2012-05-09 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Synthesis, X-Ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors. J.Med.Chem., 55, 2012
一类新型内酰胺基HIV-1蛋白酶抑制剂的立体选择性合成、X射线分析与生物学评价
描述项：甲基((S)-1-(2-(3-((3S,4S)-3-苄基-4-羟基-1-((1S,2R)-2-羟基-2,3-二氢-1H-茚-1-基)-2-氧代吡咯烷-3-基)丙基)-2-(4-(吡啶-4-基)苄基)肼基)-3,3-二甲基-1-氧代丁烷-2-基)氨基甲酸酯，POL蛋白
作者：Wu X、Ohrngren P、Joshi A.A、Trejos A、Persson M、Unge J、Arvela R.K、Wallberg H、Vrang L、Rosenquist A、Samuelsson B.B、Unge J、Larhed M
提交日期：2011-11-01
发布日期：2012-05-09
最后修改日期：2024-05-01
测试方法：X射线衍射（1.5 Å）
引用文献：《一类新型立体纯内酰胺基HIV-1蛋白酶抑制剂的合成、X射线分析与生物学评价》，J.Med.Chem.，55卷，2012年
创建时间：
2011-11-01
