Additional file 1 of The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons

Supplementary Material 1. Supplementary Table 1: QTL datasets used for analyses. Supplementary Table 2. Study population. Supplementary Table 3: Coverage details for CTSB. Supplemental Table 4: Primer and gRNA sequences used in the generation of CTSB-KO iPSC lines. Supplementary Table 5: Cell Culture Reagents and Media Compositions. Supplemental Table 6: CRISPRa and CRISPRi gRNA sequences. Supplemental Table 7: Antibodies. Supplemental Table 8: qPCR Primer sequences. Supplementary Table 9: GCTA-COLOC results. Supplementary Table 10: FINEMAP results of the nominated variants in CTSB. Supplementary Table 11: CTSB locus SMR and HEIDI analyses. Supplemental Table 12: Burden analysis for CTSB rare variants. Supplemental Table 13: gnomAD CTSB LOF. Supplemental Table 14: gnomAD SV CTSB.