Efficacy of PHiD-CV against first community-acquired pneumonia and invasive pneumococcal disease episodes.

VE estimated as one minus the hazard ratio and obtained, with its 95% CI, from a Cox regression model based on time to first episode when at least one event was observed in each group and conditional on number of cases when no case in at least one group (i.e., VE equal to zero or −infinite (VE, 1 − [x/0]).aNumber of first episodes during the respective follow-up period divided by n, multiplied by 100.bSignificant p-value (p = 0.002); one-sided p-value from Cox regression model to test null hypothesis VE ≤ 0% with one-sided alpha of 1.75%.cS. pneumoniae was isolated from all culture-confirmed invasive disease cases.dPneumococcal serotype 6A, 9N, or 19A.NC, not calculable.