Cattleyak exhibit equivalent adaptability to harsh environment as yak and much higher performances than yak. However, F1 male infertility of cattleyak due to spermatogenic arrest greatly restricts the
Tissue-specific transcriptional factors often play key roles in the development of specific cell lineages. Transcription factor-like 5 (TCFL5) is a testis-specific protein that contains the basic heli
Male sterility line plays an important role in hybrid seed production via exploiting heterosis. The difference expression genes related to pollen development between male sterility and maintain line w
Activation of the Heat Shock Factor 1 (HSF1) in spermatogenic cells leads to apoptosis and infertility of males. To elucidate a mechanisms of apoptosis induced by HSF1 we generated transgenic mice exp
Constitutive activation of the WNT signaling effector CTNNB1 (β-catenin) in the Sertoli cells of the Ctnnb1tm1Mmt/+;Amhr2tm3(cre)Bhr/+ mouse model results in progressive germ cell loss and sterility.