Crystal Structure of beta secetase in complex with (6S)-2-amino-3,6-dimethyl-6-[(1R,2R)-2-phenylcyclopropyl]-3,4,5,6-tetrahydropyrimidin-4-one

Protein Data Bank Japan2024-11-20 更新2026-03-21 收录

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Crystal Structure of beta secetase in complex with (6S)-2-amino-3,6-dimethyl-6-[(1R,2R)-2-phenylcyclopropyl]-3,4,5,6-tetrahydropyrimidin-4-one Descriptor: (6S)-2-amino-3,6-dimethyl-6-[(1R,2R)-2-phenylcyclopropyl]-5,6-dihydropyrimidin-4(3H)-one, Beta-secretase 1, DIMETHYL SULFOXIDE, ... Authors: Yonezawa, S, Fujiwara, K, Yamamoto, T, Hattori, K, Yamakawa, H, Muto, C, Hosono, M, Tanaka, Y, Nakano, T, Takemoto, H, Arisawa, M, Shuto, S. Deposit date: 2013-05-13 Release date: 2013-10-02 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.501 Å) Cite: Conformational restriction approach to beta-secretase (BACE1) inhibitors III: Effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations Bioorg.Med.Chem., 21, 2013

与(6S)-2-氨基-3,6-二甲基-6-[(1R,2R)-2-苯基环丙基]-3,4,5,6-四氢嘧啶-4-酮结合的β分泌酶晶体结构 Descriptor: (6S)-2-氨基-3,6-二甲基-6-[(1R,2R)-2-苯基环丙基]-5,6-二氢嘧啶-4(3H)-酮、β分泌酶1（Beta-secretase 1）、二甲基亚砜（DIMETHYL SULFOXIDE）…… Authors: Yonezawa, S、Fujiwara, K、Yamamoto, T、Hattori, K、Yamakawa, H、Muto, C、Hosono, M、Tanaka, Y、Nakano, T、Takemoto, H、Arisawa, M、Shuto, S. 入库日期：2013-05-13 发布日期：2013-10-02 最后更新日期：2024-11-20 Method: X射线衍射（2.501 Å） Cite: 《β分泌酶（BACE1）抑制剂的构象限制研究Ⅲ：联合X射线分析、等温滴定量热法与理论计算有效探究结合模式》，《Bioorg.Med.Chem.》，21, 2013

创建时间：

2013-05-13