Relative accessability of HSV1 genomic DNA compared with its host cell (ATAC-seq). Relative accessability of HSV1 genomic DNA compared with its host cell (ATAC-seq)

To compare the relative accessability of HSV1 DNA compared with its host DNA, we performed ATAC-seq analysis. Overall design: Cells were left uninfected; infected for 2, 4, or 6 hours; or infected for 6 hours in the presence of phosphonoacetic acid to prevent genome replication. ATAC-seq was performed as per standard published protocols.